CAS No. 7773-01-5
Batch:
Purity:98
Chemical Structure
Check the
Manganese chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | manganese(2+) dichloride | |
|---|---|---|
| CAS Number | 7773-01-5 | |
| Molecular Formula |
MnCl2 |
|
| Molecular Weight (MW) | 125.84 | |
| InChIKey | GLFNIEUTAYBVOC-UHFFFAOYSA-L |
Manganese chloride is an inorganic salt and essential cofactor that functions as an activator of cyclic GMP-AMP synthase (cGAS) and integrin receptors. It enhances cGAS enzymatic activity and sensitizes double-stranded DNA recognition, thereby activating the cGAS-STING signaling pathway to stimulate type I interferon production and innate immune responses. Additionally, manganese ions promote integrin activation, facilitating cell adhesion and downstream intracellular signaling cascades.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.