Home Immunology & Inflammation TpoR agonist Lusutrombopag For research use only.

Lusutrombopag

Synonyms: S-888711

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist being developed for chronic liver disease (CLD).

Lusutrombopag Chemical Structure

Lusutrombopag Chemical Structure

CAS: 1110766-97-6

Purity & Quality Control

Batch: Purity: 99.92%
99.92

Lusutrombopag Related Products

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Biological Activity

Description Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist being developed for chronic liver disease (CLD).
Targets
TPO receptor [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02389621 Completed
Chronic Liver Disease|Thrombocytopenia
Shionogi|Shionogi Inc.
 June 15 2015 Phase 3
NCT01054443 Terminated
Immune Thrombocytopenia (ITP)
Shionogi|Shionogi Inc.
 March 18 2010 Phase 2
NCT03897413 Completed
Healthy Volunteer
Shionogi|Shionogi Inc.
 November 6 2009 Phase 1

Chemical Information & Solubility

Molecular Weight 591.55 Formula

C29H32Cl2N2O5S
CAS No. 1110766-97-6 SDF --
Smiles CCCCCCOC(C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(\C=C(/C)C(O)=O)C(=C3)Cl)Cl
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (169.04 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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