CAS No. 1110766-97-6

Batch: Purity:99.92
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Lusutrombopag Chemical Structure
Chemical Structure
Check the Lusutrombopag product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (E)-3-[2,6-dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid
CAS Number 1110766-97-6
Molecular Formula

C29H32Cl2N2O5S
Molecular Weight (MW) 591.55
SMILES CCCCCCOC(C)C1=CC=CC(=C1OC)C2=CSC(=N2)NC(=O)C3=CC(=C(\C=C(/C)C(O)=O)C(=C3)Cl)Cl
InChIKey NOZIJMHMKORZBA-KJCUYJGMSA-N

Biological Activity

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist. It selectively binds to the transmembrane domain of the human TPO receptor, activating downstream signaling pathways including STAT3, STAT5, AKT/mTOR, and MAPK/ERK. Activation of these pathways promotes the proliferation and differentiation of megakaryocytic progenitor cells, ultimately driving megakaryocytopoiesis and increasing platelet production without competing with endogenous thrombopoietin. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (169.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Biological & Pharmaceutical Bulletin. 2015;38(4):634-634.

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Note: Technical data last updated: Sep 1, 2026.