CAS No. 119425-90-0
Batch:
Purity:99.54
Chemical Structure
Check the
Loureirin B
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one | |
|---|---|---|
| CAS Number | 119425-90-0 | |
| Molecular Formula |
C18H20O5 |
|
| Molecular Weight (MW) | 316.35 | |
| SMILES | COC1=CC(=C(CCC(=O)C2=CC=C(O)C=C2)C(=C1)OC)OC | |
| InChIKey | ZPFRAPVRYLGYEC-UHFFFAOYSA-N |
Loureirin B is a natural flavonoid extracted from Dracaena cochinchinensis that acts as an inhibitor of plasminogen activator inhibitor-1 (PAI-1). It downregulates p-ERK and p-JNK signaling in TGF-β1-stimulated fibroblasts to attenuate fibrotic phenotypes. In addition, Loureirin B promotes insulin secretion by upregulating Pdx-1 and MafA expression, increasing intracellular ATP, inhibiting KATP channels, and stimulating intracellular Ca2+ influx.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(316.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.