Losartan Carboxylic Acid (EXP-3174)

For research use only.

Catalog No.S5980 Synonyms: E-3174

Losartan Carboxylic Acid (EXP-3174) Chemical Structure

CAS No. 124750-92-1

Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.

Purity & Quality Control

Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Losartan Carboxylic Acid (E-3174, EXP-3174), an active carboxylic acid metabolite of Losartan, is a non-peptide angiotensin II (AT1) receptor antagonist. Losartan Carboxylic Acid inhibits the specific binding of [125I]-angiotensin II to VSMC with IC50 of 1.1 nM.
Targets
binding of [125I]-angiotensin II to VSMC [1]
(Cell-free assay)
1.1 nM

Protocol

Solubility (25°C)

In vitro DMSO 87 mg/mL (199.13 mM)
Water Insoluble
Ethanol ''87 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 436.89
Formula

C22H21ClN6O2

CAS No. 124750-92-1
Storage powder
in solvent
Synonyms E-3174

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04322266 Completed Drug: HCP1701|Drug: HCP1306|Drug: HGP0904|Drug: HGP0608 Healthy Hanmi Pharmaceutical Company Limited December 21 2018 Phase 1
NCT04081844 Completed Drug: HCP1306|Drug: HGP0904|Drug: HGP0608 Healthy Hanmi Pharmaceutical Company Limited May 3 2018 Phase 1
NCT00732966 Unknown status Drug: losartan|Drug: valsartan Hypertension Assaf-Harofeh Medical Center September 2008 Not Applicable

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID