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Larazotide

Name: Larazotide
Brand: Selleck Chemicals
SKU: E2035
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E2035

Larazotide(AT-1001) is an antagonist of Zonulin, which appears safe and well-tolerated and may offer potential benefit as an adjuvant to immune-targeted therapies.

Chemical Structure

Molecular Weight: 725.83

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Quality Control

Batch: Purity: 98.82%

98.82

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Solubility

In vitro
Batch:

Water : 25 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	725.83	Formula	C₃₂H₅₅N₉O₁₀	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	258818-34-7	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	AT-1001			Smiles	CC(C)CC(NC(=O)C(NC(=O)CNC(=O)CN)C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NCC(O)=O

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/35211683/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01396213	Completed	Celiac Disease	9 Meters Biopharma Inc.\|Teva Pharmaceuticals USA	November 7 2011	Phase 2
NCT00620451	Completed	Celiac Disease	9 Meters Biopharma Inc.	February 2008	Phase 2
NCT00362856	Completed	Celiac Disease	9 Meters Biopharma Inc.	September 13 2006	Phase 2
NCT00386490	Completed	Healthy	9 Meters Biopharma Inc.	January 10 2006	Phase 1
NCT00386165	Completed	Celiac Disease	9 Meters Biopharma Inc.	November 29 2005	Phase 1

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Handling Instructions

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