CAS No. 258818-34-7

Batch: Purity:98.82
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Larazotide Chemical Structure
Chemical Structure
Check the Larazotide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 258818-34-7
Molecular Formula

C32H55N9O10
Molecular Weight (MW) 725.83
SMILES CC(C)CC(NC(=O)C(NC(=O)CNC(=O)CN)C(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(N)=O)C(=O)N1CCCC1C(=O)NCC(O)=O

Ordering Information

Biological Activity

Larazotide (AT-1001) is a synthetic octapeptide tight junction regulator and antagonist of zonulin. By blocking zonulin receptor binding, larazotide prevents tight junction disassembly and actin cytoskeleton rearrangement, thereby maintaining intestinal epithelial barrier integrity. This inhibition blocks the paracellular passage of luminal antigens such as gliadin peptides across the mucosal barrier, suppressing downstream antigen trafficking and inflammatory signaling cascades in preclinical models of intestinal hyperpermeability.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 25 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.