L-Cystine

Catalog No.S4808 Batch:S480801

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Technical Data

Formula

C6H12N2O4S2
Molecular Weight 240.30 CAS No. 56-89-3
Solubility (25°C)* In vitro 0.5MNAOH 6.02 mg/mL (25.05 mM)
DMSO 0.001 mg/mL (0.0 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description L-Cystine is the oxidized dimer form of the amino acid L-cysteine which is a non-essential amino acid of the human body. It is required for wound healing and formation of epithelial tissue.
In vitro L-cysteine can enhance proliferation and differentiation of NSCs via the CBS/H2S pathway[1].
In vivo L-Cysteine dose-dependently decreases food intake in both rats and mice following oral gavage and intraperitoneal administration. L-Cysteine increases neuronal activation in the area postrema and delayed gastric emptying. It suppresses plasma acyl ghrelin levels and does not reduce food intake in transgenic ghrelin-overexpressing mice. Repeated L-cysteine administration decreases food intake in rats and obese mice. L-Cysteine reduces hunger and plasma acyl ghrelin levels in humans[2].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    Neural stem cells (NSCs)

  • Concentrations

    0.1, 0.5, 1, 5, 10 and 50 μM

  • Incubation Time

    24 and 48 h

  • Method

    NSCs are seeded at 96-well plates and then treated with the indicated concentrations of L-cysteine (L-cys) for 24 and 48 h in reduced growth medium. NSCs proliferation is measured by MTT analysis.
Animal Study:[1]
  • Animal Models

    Male C57BL/6 mice

  • Dosages

    2 mmol/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.