Home Microbiology HBV modulator JNJ-632

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JNJ-632 HBV modulator

Cat.No.S0796

JNJ-632 is a potent hepatitis B virus (HBV) capsid assembly modulator (CAM) with mean EC50 of 121 nM in HepG2.2.15 cells.
JNJ-632 HBV modulator Chemical Structure

Chemical Structure

Molecular Weight: 378.42

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Quality Control

Batch: S079601 DMSO]76 mg/mL]false]Ethanol]76 mg/mL]false]Water]Insoluble]false Purity: 99.95%
99.95

Solubility

In vitro
Batch:

DMSO : 76 mg/mL (200.83 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 76 mg/mL

Water : Insoluble

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
% Tween 80
% ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 378.42 Formula

C18H19FN2O4S

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1572510-42-9 -- Storage of Stock Solutions

Synonyms N/A Smiles CC1=C(C=CC(=C1)NC(=O)C2=CC(=CC=C2)S(=O)(=O)NC3CCOC3)F

Mechanism of Action

Targets/IC50/Ki
HBV capsid
(in HepG2.2.15 cells)
121 nM(EC50)
In vitro

JNJ-632 shows similar anti-HBV activities across all four genotypes tested, with the EC50s for genotypes A to D being 101, 240, 119, and 200 nM, respectively, by preventing formation of covalently closed circular DNA in a dose-dependent fashion.
In vivo

JNJ-632, a N-phenyl-3-sulfamoyl-benzamide derivative and HBV capsid assembly modulator, can inhibit HBV in vivo (HBV infected humanized mice) resulting in a 2.77 log reduction of HBV DNA viral load.
References

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