CAS No. 945526-43-2
Batch:
Purity:99.76
Chemical Structure
Check the
ISCK03
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide | |
|---|---|---|
| CAS Number | 945526-43-2 | |
| Molecular Formula |
C19H21N3O2S
|
|
| Molecular Weight (MW) | 355.45 | |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3 | |
| InChIKey | XQABBHBFHWHMKF-UHFFFAOYSA-N |
Biological Activity
ISCK03 is a cell-permeable small-molecule inhibitor targeting the stem-cell factor (SCF) and c-Kit signaling pathway. By blocking SCF-induced receptor tyrosine phosphorylation of c-Kit, ISCK03 suppresses downstream activation of the ERK/MAPK pathway. This inhibition impairs c-Kit-mediated signaling cascades, ultimately modulating downstream cell proliferation, survival, and functional phenotypes dependent on active SCF/c-Kit signaling. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.