Imidacloprid-urea

Catalog No.S4448 Batch:S444801

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Technical Data

Formula

C9H10ClN3O
Molecular Weight 211.65 CAS No. 120868-66-8
Solubility (25°C)* In vitro DMSO 42 mg/mL (198.44 mM)
Ethanol 21 mg/mL (99.22 mM)
Water 5 mg/mL (23.62 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Imidacloprid-urea with a role as a marine xenobiotic metabolite, is the primary imidacloprid soil metabolite, whereas imidacloprid-olefin is the main plant-relevant metabolite and is more toxic to insects than imidacloprid.
In vitro

Imidacloprid urea is a metabolite of imidacloprid. Imidacloprid is an effective and widely used neonicotinoid pesticide to control pests of cereals, vegetables, tea and cotton. Imidacloprid can reduce insulin stimulated glucose uptake in adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12) cell culture models. Treatment with imidacloprid inhibits phosphorylation of protein kinase B (AKT) and ribosomal S6 kinase (S6K).[2]
In vivo

The brain, liver and kidney of rats exposed with high dose of imidacloprid(20mg/kg/day) show mild pathological changes. [3]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    3T3-L1, HepG2, C2C12

  • Concentrations

    0 μM, 10 μM, 20 μM

  • Incubation Time

    4-6 days

  • Method

    3T3-L1, HepG2, and C2C12 are treated with imidacloprid (0, 10, and 20 μM) for 4-6 days followed by treatment with insulin for 15 min to determine responses. Insulin stimulated glucose uptake and the expressions of p-AKT and p-S6K are determined in all three cells.
Animal Study:

[3]
  • Animal Models

    Female rats (Rattus norvigicus Wistar strain)

  • Dosages

    5 mg/kg, 10 mg/kg, 20 mg/kg

  • Administration

    o.g.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.