CAS No. 2095432-71-4

Batch: Purity:99.59
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GSK269962A HCl Chemical Structure
Chemical Structure
Check the GSK269962A HCl product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethylimidazo[4,5-c]pyridin-6-yl]oxyphenyl]-4-(2-morpholin-4-ylethoxy)benzamide;hydrochloride
CAS Number 2095432-71-4
Molecular Formula

C29H30N8O5.HCl
Molecular Weight (MW) 607.06
SMILES CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6.Cl
InChIKey UYKVMFKKKLLDGL-UHFFFAOYSA-N

Biological Activity

GSK269962A HCl is a potent and selective Rho-associated protein kinase (ROCK) inhibitor, targeting ROCK1 (IC50 1.6 nM) and ROCK2 (IC50 4 nM). By impairing ROCK-mediated kinase activity within the ROCK pathway, this compound suppresses downstream substrate phosphorylation required for actin cytoskeletal reorganization and smooth muscle contraction, thereby inhibiting cell migration, reducing vascular tone, and suppressing pathological cell proliferation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (164.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 28 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Doe C, et al. J Pharmacol Exp Ther. 2007;320(1):89-98.

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Note: Technical data last updated: Sep 1, 2026.