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FAZ-3532

FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study the immunological role of stress granules during viral infection.

FAZ-3532 Chemical Structure

FAZ-3532 Chemical Structure

CAS No. 3036029-72-5

Purity & Quality Control

Batch: E592801 DMSO]100 mg/mL]false]Ethanol]50 mg/mL]false]Water]Insoluble]false Purity: 99.53%
99.53

FAZ-3532 Related Products

Biological Activity

Description FAZ-3532 is a potent inhibitor of G3BP that binds to G3BP1 with a Kd of 0.54 μM, inhibiting co-condensation of G3BP1, Caprin1, and RNA, and blocking stress granule formation in cells. It specifically targets the protein–protein interaction within the NTF2L domain of G3BP1 without affecting its dimerization or RNA-binding, making it a useful tool to study the immunological role of stress granules during viral infection.
  • https://pubmed.ncbi.nlm.nih.gov/38284934/

Chemical Information & Solubility

Molecular Weight 713.88 Formula

C38H56FN5O7
CAS No. 3036029-72-5 SDF Download FAZ-3532 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (140.07 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 50 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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