Entacapone

Catalog No.S3147 Synonyms: OR-611

For research use only.

Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.

Entacapone Chemical Structure

CAS No. 130929-57-6

Selleck's Entacapone has been cited by 2 Publications

Purity & Quality Control

Choose Selective Histone Methyltransferase Inhibitors

Biological Activity

Description Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM. Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.
Targets
COMT [1]
151 nM
In vitro

Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. [1] Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 305.29
Formula

C14H15N3O5

CAS No. 130929-57-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCN(CC)C(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C#N

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02058966 Completed Drug: Entacapone|Drug: Methamphetamine|Drug: Placebo Methamphetamine Dependence Oregon Health and Science University|Portland VA Medical Center June 2014 Early Phase 1
NCT00547911 Terminated Drug: Droxidopa|Drug: Carbidopa|Drug: Entacapone Parkinson Disease|Multiple System Atrophy|Autonomic Nervous System Diseases National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) October 2007 Phase 1|Phase 2
NCT00415922 Completed Drug: ELC200 (carbidopa+levodopa+entacapone) Healthy Novartis July 2006 Phase 1
NCT00415831 Completed Drug: ELC200 (carbidopa+levodopa+entacapone) Healthy Novartis June 2006 Phase 1
NCT00415844 Completed Drug: ELC200 (carbidopa+levodopa+entacapone) Healthy Novartis June 2006 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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