For research use only.
Catalog No.S3147 Synonyms: OR-611
CAS No. 130929-57-6
Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.
Purity & Quality Control
Choose Selective Histone Methyltransferase Inhibitors
|Description||Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.|
Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues.  Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. 
|In vitro||DMSO||61 mg/mL (199.81 mM)|
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
In vivo Formulation Calculator (Clear solution)
|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
|Dosage||mg/kg||Average weight of animals||g||Dosing volume per animal||ul||Number of animals|
|Step 2: Enter the in vivo formulation ()|
|% DMSO % % Tween 80 % ddH2O|
Working concentration： mg/ml；
Method for preparing DMSO master liquid: ： mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，)
Method for preparing in vivo formulation：Take DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH2O，mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
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Molecular Weight Calculator
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT02058966||Completed||Drug: Entacapone|Drug: Methamphetamine|Drug: Placebo||Methamphetamine Dependence||Oregon Health and Science University|Portland VA Medical Center||June 2014||Early Phase 1|
|NCT00547911||Terminated||Drug: Droxidopa|Drug: Carbidopa|Drug: Entacapone||Parkinson Disease|Multiple System Atrophy|Autonomic Nervous System Diseases||National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC)||October 2007||Phase 1|Phase 2|
|NCT00415922||Completed||Drug: ELC200 (carbidopa+levodopa+entacapone)||Healthy||Novartis||July 2006||Phase 1|
|NCT00415831||Completed||Drug: ELC200 (carbidopa+levodopa+entacapone)||Healthy||Novartis||June 2006||Phase 1|
|NCT00415844||Completed||Drug: ELC200 (carbidopa+levodopa+entacapone)||Healthy||Novartis||June 2006||Phase 1|
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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