Entacapone

Catalog No.S3147 Synonyms: OR-611

Entacapone Chemical Structure

Molecular Weight(MW): 305.29

Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.

Size Price Stock Quantity  
In DMSO USD 190 In stock
USD 147 In stock
USD 770 In stock
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Biological Activity

Description Entacapone inhibits catechol-O-methyltransferase(COMT) with IC50 of 151 nM.
Targets
COMT [1]
()
151 nM
In vitro

Entacapone inhibits catechol-O-methyltransferase(COMT) with similar IC50 in different tissues including live, duodenum, kidney and lung, but entacapone is more active than tolcapone in those tissues. [1] Entacapone (< 100 μM) is a potent inhibitor of α-syn and β-amyloid (Aβ) oligomerization and fibrillogenesis, and also protects against extracellular toxicity induced by the aggregation of both proteins in PC12 cells. [2]

Protocol

Solubility (25°C)

In vitro DMSO 61 mg/mL (199.81 mM)
Ethanol 2 mg/mL (6.55 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 305.29
Formula

C14H15N3O5

CAS No. 130929-57-6
Storage powder
in solvent
Synonyms OR-611

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT02058966 Completed Drug: Entacapone|Drug: Methamphetamine|Drug: Placebo Methamphetamine Dependence Oregon Health and Science University|Portland VA Medical Center June 2014 Early Phase 1
NCT00547911 Terminated Drug: Droxidopa|Drug: Carbidopa|Drug: Entacapone Parkinson Disease|Multiple System Atrophy|Autonomic Nervous System Diseases National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) October 2007 Phase 1|Phase 2
NCT00415922 Completed Drug: ELC200 (carbidopa+levodopa+entacapone) Healthy Novartis July 2006 Phase 1
NCT00415831 Completed Drug: ELC200 (carbidopa+levodopa+entacapone) Healthy Novartis June 2006 Phase 1
NCT00415844 Completed Drug: ELC200 (carbidopa+levodopa+entacapone) Healthy Novartis June 2006 Phase 1

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Histone Methyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID