CAS No. 130929-57-6
| IUPAC Name | (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide | |
|---|---|---|
| CAS Number | 130929-57-6 | |
| Molecular Formula |
C14H15N3O5 |
|
| Molecular Weight (MW) | 305.29 | |
| SMILES | CCN(CC)C(=O)C(=CC1=CC(=C(C(=C1)O)O)[N+](=O)[O-])C#N | |
| InChIKey | JRURYQJSLYLRLN-BJMVGYQFSA-N |
Entacapone (OR-611) is a potent inhibitor of catechol-O-methyltransferase (COMT) and fat mass and obesity-associated protein (FTO) demethylation. By blocking COMT activity, it prevents the peripheral breakdown of levodopa, enhancing dopamine availability in central signaling pathways. Additionally, inhibition of FTO demethylase activity regulates metabolic homeostasis, impacting gluconeogenesis and energy expenditure. Entacapone is widely utilized in research addressing Parkinson's disease and metabolic disorders. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(199.81 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 2 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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