Dexrazoxane

Name: Dexrazoxane
Brand: Selleck Chemicals
SKU: S5651
Rating: 5 (9 reviews)

Synonyms: ICRF-187

Catalog No.S5651 Purity: 99.95%

Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Dexrazoxane Chemical Structure

CAS: 24584-09-6

Selleck's Dexrazoxane has been cited by 9 publications

Purity & Quality Control

Batch: Purity: 99.95%

99.95

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Biological Activity

Description	Dexrazoxane (ICRF-187) is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

In vitro
In vitro	Topoisomerase 2 (Top2) inhibition with dexrazoxane combined with dBET6 in HeLa cells increases DNA damage signaling at proximal time points.^[1]
Cell Research	Cell lines	HeLa cells
	Concentrations	50 μM J60
	Incubation Time	4 h
	Method	HeLa cells are treated with 50 μM dexrazoxane for 4 h. Cell lysates are used for detecting the levels of BRD4, RNAPIIpS2 and γH2AX by western blots.

In Vivo
In vivo	Dexrazoxane prevents doxorubicin induced late-onset cardiomyopathy and also protected the cardiac mitochondria from acquired ultrastructural, genetic and functional damage.

References

[1] Edwards DS, et al. Cell Rep. 2020 Sep 22;32(12):108166.

Chemical Information & Solubility

Molecular Weight	268.27	Formula	C₁₁H₁₆N₄O₄
CAS No.	24584-09-6	SDF	--
Smiles	CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 54 mg/mL ( (201.28 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

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In vivo
Batch:

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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