Dexrazoxane

Catalog No.S5651 Synonyms: ICRF-187

Dexrazoxane Chemical Structure

Molecular Weight(MW): 268.27

Dexrazoxane is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

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Purity & Quality Control

Biological Activity

Description Dexrazoxane is an anticancer drug able to block mitosis and to arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Protocol

References

Solubility (25°C)

In vitro DMSO 54 mg/mL (201.28 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 268.27
Formula

C11H16N4O4

CAS No. 24584-09-6
Storage powder
in solvent
Synonyms ICRF-187

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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  • Computed Result

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    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03786783 Recruiting Ganglioneuroblastoma|High-Risk Neuroblastoma|NMYC Gene Amplification National Cancer Institute (NCI) January 14 2019 Phase 2
NCT03786783 Recruiting Ganglioneuroblastoma|High-Risk Neuroblastoma|NMYC Gene Amplification National Cancer Institute (NCI) January 14 2019 Phase 2
NCT03698227 Recruiting Advanced Soft Tissue Sarcoma IKF Klinische Krebsforschung GmbH at Krankenhaus Nordwest November 12 2018 Phase 2
NCT03698227 Recruiting Advanced Soft Tissue Sarcoma IKF Klinische Krebsforschung GmbH at Krankenhaus Nordwest November 12 2018 Phase 2
NCT03589729 Recruiting Acute Myeloid Leukemia|Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Blasts 10 Percent or More of Bone Marrow Nucleated Cells|High Risk Myelodysplastic Syndrome|Myeloid Sarcoma|Myeloproliferative Neoplasm|Philadelphia Chromosome Positive M.D. Anderson Cancer Center|National Cancer Institute (NCI) September 19 2018 Phase 2
NCT03589729 Recruiting Acute Myeloid Leukemia|Blast Phase Chronic Myelogenous Leukemia BCR-ABL1 Positive|Blasts 10 Percent or More of Bone Marrow Nucleated Cells|High Risk Myelodysplastic Syndrome|Myeloid Sarcoma|Myeloproliferative Neoplasm|Philadelphia Chromosome Positive M.D. Anderson Cancer Center|National Cancer Institute (NCI) September 19 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID