CAS No. 24584-09-6
Batch:
Purity:99.95
Chemical Structure
Check the
Dexrazoxane
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 24584-09-6 | |
|---|---|---|
| Molecular Formula |
C11H16N4O4 |
|
| Molecular Weight (MW) | 268.27 | |
| SMILES | CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2 |
Dexrazoxane (ICRF-187) is a catalytic topoisomerase II inhibitor and iron chelator that provides cardioprotection against anthracycline-induced toxicity. By binding to topoisomerase II and inducing topoisomerase IIβ degradation, Dexrazoxane prevents doxorubicin-mediated DNA double-strand breaks and suppresses downstream apoptotic pathways in cardiomyocytes. In addition, its iron-chelating activity reduces oxidative stress, mitigating cardiac cell death while arresting dividing cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
166.7 mg/mL
(621.38 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
54 mg/mL
(201.28 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.