Desipramine Hydrochloride

Catalog No.S5485 Synonyms: Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901

Desipramine Hydrochloride Chemical Structure

Molecular Weight(MW): 302.84

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

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USD 97 In stock
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Biological Activity

Description Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective norepinephrine reuptake inhibitor. It also shows weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects.

Protocol

References

Solubility (25°C)

In vitro DMSO 60 mg/mL (198.12 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 302.84
Formula

C18H22N2.HCl

CAS No. 58-28-6
Storage powder
in solvent
Synonyms Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01899326 Unknown status DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma|Refractory Plasma Cell Myeloma Albert Einstein College of Medicine|National Cancer Institute (NCI) December 2012 Not Applicable
NCT01899326 Unknown status DS Stage I Plasma Cell Myeloma|DS Stage II Plasma Cell Myeloma|DS Stage III Plasma Cell Myeloma|Refractory Plasma Cell Myeloma Albert Einstein College of Medicine|National Cancer Institute (NCI) December 2012 Not Applicable
NCT00964886 Completed Back Pain VA Office of Research and Development|University of California San Diego January 2010 Phase 2
NCT00964886 Completed Back Pain VA Office of Research and Development|University of California San Diego January 2010 Phase 2
NCT00913822 Completed Depression Sandoz December 1987 Phase 1
NCT00913822 Completed Depression Sandoz December 1987 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID