CAS No. 58-28-6

Batch: Purity:99.97
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Desipramine Hydrochloride Chemical Structure
Chemical Structure
Check the Desipramine Hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 58-28-6
Molecular Formula

C18H22N2.HCl
Molecular Weight (MW) 302.84
SMILES CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

Ordering Information

Biological Activity

Desipramine hydrochloride is a dibenzazepine-derivative tricyclic antidepressant that acts as a selective inhibitor of the norepinephrine transporter. By blocking norepinephrine reuptake into presynaptic neurons, it increases extracellular norepinephrine concentrations and enhances monoaminergic signaling in the central nervous system. Additionally, it exhibits weak serotonin reuptake inhibitory activity alongside antagonist effects at histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (198.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 60 mg/mL
Ethanol 60 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.