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Deruxtecan

Name: Deruxtecan
Brand: Selleck Chemicals
SKU: S9795
Rating: 5 (1 reviews)

Catalog No.S9795 Purity: 99.86%

Deruxtecan is an ADC drug-linker conjugate composed of the cleavable glycine–glycine–phenylalanine–glycine tetrapeptide-based linker, a self-immolative amino methylene spacer, and a novel topoisomerase 1 inhibitor payload that is a derivative of exatecan (DX-8951).

Deruxtecan Chemical Structure

CAS: 1599440-13-7

Purity & Quality Control

Batch: S979501 DMSO] 100 mg/mL] false] ] ] false] ] ] false Purity: 99.86%

99.86

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Biological Activity

Description	Deruxtecan is an ADC drug-linker conjugate composed of the cleavable glycine–glycine–phenylalanine–glycine tetrapeptide-based linker, a self-immolative amino methylene spacer, and a novel topoisomerase 1 inhibitor payload that is a derivative of exatecan (DX-8951).

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05620914	Not yet recruiting	Brain Metastases Adult	Mustafa Khasraw MBChB MD FRCP FRACP\|Daiichi Sankyo Inc.\|Duke University	January 2024	Early Phase 1
NCT05480384	Recruiting	Esophageal Adenocarcinoma\|Esophageal Cancer\|HER-2 Protein Overexpression\|Gastroesophageal-junction Cancer	Brown University\|AstraZeneca	July 14 2023	Phase 2
NCT05866432	Recruiting	Breast Cancer Stage IV	Medical University of Vienna\|Daiichi Sankyo Inc.	July 1 2023	Phase 2
NCT05905939	Recruiting	Breast Cancer	AstraZeneca	May 31 2023	--

References

[1] A Yver, et al. Ann Oncol . 2020 Mar;31(3):430-434.

Chemical Information & Solubility

Molecular Weight	1034.05	Formula	C₅₂H₅₆FN₉O₁₃
CAS No.	1599440-13-7	SDF	--
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 100 mg/mL ( (96.7 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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