CAS No. 1599440-13-7
Batch:
Purity:99.86
Chemical Structure
Check the
Deruxtecan
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(2,5-dioxopyrrol-1-yl)-N-[2-[[2-[[(2S)-1-[[2-[[2-[[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]amino]-2-oxoethoxy]methylamino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]hexanamide | |
|---|---|---|
| CAS Number | 1599440-13-7 | |
| Molecular Formula |
C52H56FN9O13 |
|
| Molecular Weight (MW) | 1034.05 | |
| InChIKey | WXNSCLIZKHLNSG-MCZRLCSDSA-N |
Deruxtecan is an antibody-drug conjugate (ADC) drug-linker derivative containing a cleavable tetrapeptide linker and a potent topoisomerase I inhibitor payload derived from exatecan. Upon cleavage within target tumor cells, the released payload stabilizes topoisomerase I-DNA cleavage complexes, leading to DNA double-strand breaks, inhibition of DNA replication, cell cycle arrest, and apoptotic cell death in cancer cells. [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(96.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.