Notes: 1:Clickable 2:Unclickable Growth Factors SSB Repair by BER Nucleotide Synthesis DSB Repairby NHEJ tDNAIntegrity Pentose PhosphatePathway DSB Repairby HR ChromatinRemodeling HlF-1α ProteinSynthesis Normoxia PHDs Hypoxia HRE Target Genes N-ODDD PHD1-3 FIH-1 S26 Proteasome Proteasomal Degradation Pro402 Pro564 Asn803 C-ODDD Nucleus Erythropoiesis Cell Proliferation and Survival Glucose Metabolism pH Regulation Proteolysis O 2 OH pVHL Inactivation OH OH Fe(Ⅱ) FIH 3' 5' Receptor Tyrosine Kinase PTEN 4E-BPI S6 40S 60S elF-4E MNK KU70/80 hTERT hTR HAT BRCA1 bHLH A B PAS ODDD P {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }} {{ button.text }} P {{ group.title }} {{ text.text }}