Dasabuvir (ABT-333)

Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.

Dasabuvir (ABT-333) Chemical Structure

Dasabuvir (ABT-333) Chemical Structure

CAS: 1132935-63-7

Selleck's Dasabuvir (ABT-333) has been cited by 3 publications

Purity & Quality Control

Batch: S540201 DMSO] 98 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.47%
99.47

Dasabuvir (ABT-333) Related Products

Choose Selective HCV Protease Inhibitors

Biological Activity

Description Dasabuvir (ABT-333) is a non-nucleoside inhibitor of NS5B viral RNA-dependent RNA polymerase that inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates with IC50 values between 2.2 and 10.7 nM. It is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02534870 Completed
Healthy Volunteer
AbbVie
September 2015 Phase 1
NCT02734173 Completed
Hepatitis C
Ottawa Hospital Research Institute|AbbVie
July 2015 Phase 4
NCT02052349 Completed
Relative Bioavailability
AbbVie
November 2013 Phase 1
NCT01911845 Completed
Chronic Hepatitis C Infection|Chronic Hepatitis C
AbbVie
April 2013 Phase 2

Chemical Information & Solubility

Molecular Weight 493.57 Formula

C26H27N3O5S

CAS No. 1132935-63-7 SDF --
Smiles CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 98 mg/mL ( (198.55 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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