CAS No. 1132935-63-7

Batch: Purity:99.47
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Dasabuvir (ABT-333) Chemical Structure
Chemical Structure
Check the Dasabuvir (ABT-333) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide
CAS Number 1132935-63-7
Molecular Formula

C26H27N3O5S
Molecular Weight (MW) 493.57
SMILES CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
InChIKey NBRBXGKOEOGLOI-UHFFFAOYSA-N

Ordering Information

Biological Activity

Dasabuvir (ABT-333) is a non-nucleoside inhibitor of HCV NS5B RNA-dependent RNA polymerase, inhibiting recombinant NS5B polymerases from HCV genotype 1a and 1b isolates with IC50 values between 2.2 and 10.7 nM. By targeting the viral NS5B polymerase, it disrupts viral genome replication pathways and reduces viral RNA synthesis. This mechanism displays over 7,000-fold selectivity over human polymerases, suppressing hepatitis C virus replication in replicon systems. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 98 mg/mL (198.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.