CAS No. 206361-99-1
Batch:
Purity:99.89
Chemical Structure
Check the
Darunavir
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [(3aS,4R,6aR)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] N-[(2S,3R)-4-[(4-aminophenyl)sulfonyl-(2-methylpropyl)amino]-3-hydroxy-1-phenylbutan-2-yl]carbamate | |
|---|---|---|
| CAS Number | 206361-99-1 | |
| Molecular Formula |
C27H37N3O7S |
|
| Molecular Weight (MW) | 547.66 | |
| SMILES | CC(C)CN(CC(C(CC1=CC=CC=C1)NC(=O)OC2COC3C2CCO3)O)S(=O)(=O)C4=CC=C(C=C4)N | |
| InChIKey | CJBJHOAVZSMMDJ-HEXNFIEUSA-N |
Darunavir (TMC114) is a potent nonpeptidic HIV protease inhibitor that selectively targets HIV-1 protease. By binding to the active site of the viral protease, it blocks the cleavage of Gag-Pol polyproteins into functional structural components and essential viral enzymes. This inhibition prevents viral maturation, resulting in the release of non-infectious immature virus particles and effective suppression of viral replication. [1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(182.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 11 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.