Danicopan (ACH-4471)

Catalog No.S0803 Synonyms: ACH-0144471, ACH-CFDIS, ALXN 2040

For research use only.

Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Danicopan (ACH-4471) Chemical Structure

CAS No. 1903768-17-1

Purity & Quality Control

Choose Selective Complement System Inhibitors

Biological Activity

Description Danicopan (ACH-4471, ACH-0144471, ACH-CFDIS, ALXN 2040) is a potent, selective and orally active inhibitor of factor D with Kd of 0.54 nM for human Factor D. Danicopan inhibits alternative pathway of complement (APC) activity, and has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
Targets
alternative pathway of complement (APC) [1] human Factor D [1]
(Cell-free assay)
0.54 nM(Kd)

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 580.41
Formula

C26H23BrFN7O3

CAS No. 1903768-17-1
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4CC(CC4C(=O)NC5=NC(=CC=C5)Br)F

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05019521 Recruiting Drug: Danicopan|Drug: Placebo Geographic Atrophy Alexion Pharmaceuticals August 20 2021 Phase 2
NCT04451434 Completed Drug: Danicopan Healthy Alexion Pharmaceuticals August 17 2020 Phase 1
NCT04551599 Completed Drug: Danicopan Healthy Alexion Pharmaceuticals February 21 2020 Phase 1
NCT03723512 Completed Device: Non contrast-enhanced magnetic resonance imaging C3 Glomerulonephritis|C3 Glomerulopathy|Immune Complex Membranoproliferative Glomerulonephritis|IC-MPGN|Dense Deposit Disease Mario Negri Institute for Pharmacological Research|Alexion Pharmaceuticals December 6 2018 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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