CAS No. 1903768-17-1

Batch: Purity:99.99
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Danicopan Chemical Structure
Chemical Structure
Check the Danicopan product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S,4R)-1-[2-[3-acetyl-5-(2-methylpyrimidin-5-yl)indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoropyrrolidine-2-carboxamide
CAS Number 1903768-17-1
Molecular Formula

C26H23BrFN7O3
Molecular Weight (MW) 580.41
SMILES CC1=NC=C(C=N1)C2=CC3=C(C=C2)N(N=C3C(=O)C)CC(=O)N4CC(CC4C(=O)NC5=NC(=CC=C5)Br)F
InChIKey PIBARDGJJAGJAJ-NQIIRXRSSA-N

Ordering Information

Biological Activity

Danicopan is a potent, selective, and orally active small-molecule inhibitor targeting factor D with a Kd of 0.54 nM for human factor D. By reversibly binding factor D, it blocks the catalytic cleavage of factor B and prevents the formation of alternative pathway C3 convertase. This inhibition suppresses downstream alternative pathway of complement activity, preventing complement-mediated hemolysis and membrane attack complex formation. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (172.29 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.