CAS No. 63527-52-6
Batch:
Purity:99.59
Chemical Structure
Check the
Cefotaxime
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | |
|---|---|---|
| CAS Number | 63527-52-6 | |
| Molecular Formula |
C16H17N5O7S2 |
|
| Molecular Weight (MW) | 455.47 | |
| SMILES | CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O | |
| InChIKey | GPRBEKHLDVQUJE-QSWIMTSFSA-N |
Cefotaxime (HR-756) is a third-generation cephalosporin antibiotic that possesses broad-spectrum activity against Gram-positive and Gram-negative bacteria. It acts by binding to and inhibiting essential penicillin-binding proteins (PBPs), thereby disrupting peptidoglycan cross-linking during bacterial cell wall synthesis. This inhibition compromises bacterial cell wall integrity, resulting in cell lysis and bacterial death. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
91 mg/mL
(199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.