CAS No. 466-24-0
Batch:
Purity:99.92
Chemical Structure
Check the
Benzoylaconitine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 466-24-0 | |
|---|---|---|
| Molecular Formula |
C32H45NO10 |
|
| Molecular Weight (MW) | 603.70 | |
| SMILES | CCN1CC2(C(CC(C34C2C(C(C31)C5(C6C4CC(C6OC(=O)C7=CC=CC=C7)(C(C5O)OC)O)O)OC)OC)O)COC |
Benzoylaconine (Benzoylaconitine) is an aconitum alkaloid derived from Radix Aconiti Lateralis Preparata that functions as an anti-inflammatory agent. In human synovial cells, benzoylaconine attenuates IL-1β-induced pro-inflammatory responses by suppressing the production of interleukin-6 (IL-6) and interleukin-8 (IL-8). This inhibitory effect is mediated through downregulation of the MAPK, AKT, and NF-κB signaling pathways, leading to reduced inflammatory cascade activation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(165.64 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.