CAS No. 2412155-74-7

Batch: Purity:99.37
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AST5902 trimesylate Chemical Structure
Chemical Structure
Check the AST5902 trimesylate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2412155-74-7
Molecular Formula

C30H41F3N8O11S3
Molecular Weight (MW) 842.88
SMILES CNCCN(C)C1=NC(=C(NC2=NC=CC(=N2)C3=C[N](C)C4=C3C=CC=C4)C=C1NC(=O)C=C)OCC(F)(F)F.C[S](O)(=O)=O.C[S](O)(=O)=O.C[S](O)(=O)=O

Ordering Information

Biological Activity

AST5902 trimesylate is the principal active metabolite of alflutinib and functions as an irreversible epidermal growth factor receptor (EGFR) inhibitor. By targeting EGFR signaling pathways, it suppresses downstream kinase cascades involved in cell proliferation and survival, exhibiting potent antineoplastic activity against EGFR-driven tumor models. Furthermore, AST5902 displays weak CYP3A4 induction potential compared to its parent compound, maintaining high target selectivity and cellular efficacy. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 100 mg/mL
DMSO 50 mg/mL (59.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.