CAS No. 2222112-77-6
Batch:
Purity:98.78
Chemical Structure
Check the
Bavdegalutamide (ARV-110)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[4-(3-chloro-4-cyanophenoxy)cyclohexyl]-6-[4-[[4-[2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1,3-dioxoisoindol-5-yl]piperazin-1-yl]methyl]piperidin-1-yl]pyridazine-3-carboxamide | |
|---|---|---|
| CAS Number | 2222112-77-6 | |
| Molecular Formula |
C41H43ClFN9O6 |
|
| Molecular Weight (MW) | 812.29 | |
| SMILES | FC1=CC2=C(C=C1N3CCN(CC3)CC4CCN(CC4)C5=NN=C(C=C5)C(=O)NC6CCC(CC6)OC7=CC=C(C#N)C(=C7)Cl)C(=O)N(C8CCC(=O)NC8=O)C2=O | |
| InChIKey | CLCTZVRHDOAUGJ-UHFFFAOYSA-N |
Biological Activity
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that recruits an E3 ubiquitin ligase to induce targeted ubiquitination and proteasomal degradation of the AR protein. By selectively depleting AR, bavdegalutamide disrupts downstream androgen receptor signaling pathways, leading to suppressed expression of AR-regulated genes and inhibition of cell proliferation in prostate cancer models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(61.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(123.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
Jump to
- Bavdegalutamide (ARV-110) Mechanism of Action: Androgen Receptor Inhibition in Prostate Cancer Cell Research
- Bavdegalutamide (ARV-110) Clinical Trials
- Bavdegalutamide (ARV-110) Working Concentration | Cell Culture | Treatment
- Bavdegalutamide (ARV-110) Solubility in DMSO
- Bavdegalutamide (ARV-110) Stock Solution
- Bavdegalutamide (ARV-110) Storage
- Bavdegalutamide (ARV-110) Stability
- Bavdegalutamide (ARV-110) VS Bicalutamide | ARN-509 (Apalutamide) | MDV3100 (Enzalutamide)
- Bavdegalutamide (ARV-110) Molecular Weight
- Bavdegalutamide (ARV-110) SMILES
- Bavdegalutamide (ARV-110) Chemical Structure (2D and 3D)
- Bavdegalutamide (ARV-110) IC50 for Cell-based and Cell-free Assays
- Bavdegalutamide (ARV-110) Sigma (AMBH97B9F947)? Try a better option.
- Bavdegalutamide (ARV-110) Cayman (39662)? Try a better option.
- Bavdegalutamide (ARV-110) Cell Signaling Technology (16812)? Try a better option.
- Bavdegalutamide (ARV-110) AbMole (M10306)? Try a better option.
- Bavdegalutamide (ARV-110) MedChemExpress (HY-138641)? Try a better option.
- Bavdegalutamide (ARV-110) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.