CAS No. 6398-98-7

Batch: Purity:99.80
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Amodiaquine dihydrochloride dihydrate Chemical Structure
Chemical Structure
Check the Amodiaquine dihydrochloride dihydrate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol;hydrate;hydrochloride
CAS Number 6398-98-7
Molecular Formula

C20H22ClN3O.2HCl.2H2O
Molecular Weight (MW) 464.81
SMILES CCN(CC)CC1=C(C=CC(=C1)NC2=C3C=CC(=CC3=NC=C2)Cl)O.O.O.Cl.Cl
InChIKey AOFIMJMWPZOPAJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Amodiaquine dihydrochloride dihydrate is a potent, non-competitive inhibitor of histamine N-methyltransferase (HNMT) that also possesses antimalarial and anti-inflammatory activities. By blocking HNMT-mediated histamine metabolism, it modulates histamine signaling pathways involved in immune responses. Furthermore, amodiaquine acts as a Nurr1 agonist and impairs autophagic flux, suppressing pro-inflammatory cytokine expression and exhibiting protective phenotypes in disease models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 92 mg/mL (197.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 29 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.