CAS No. 112901-68-5
| CAS Number | 112901-68-5 | |
|---|---|---|
| Molecular Formula |
C5H15N2O3PS.3H2O |
|
| Molecular Weight (MW) | 268.27 | |
| SMILES | C(CN)CNCCSP(=O)(O)O.O.O.O |
Amifostine trihydrate is a broad-spectrum cytoprotective agent and radioprotectant. As a prodrug, it is dephosphorylated by cell-surface alkaline phosphatase to its active free thiol metabolite, WR-1065. WR-1065 directly scavenges reactive oxygen species and inactivates toxic chemotherapeutic metabolites. Through this ROS-scavenging mechanism, amifostine attenuates oxidative stress, reduces DNA damage, and prevents apoptosis in normal tissues during cisplatin chemotherapy and radiation therapy. [1]
| Solvent | Solubility & Note |
|---|---|
| Water | 54 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
| Water | 42 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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