CAS No. 66376-36-1
Batch:
Purity:98
Chemical Structure
Check the
Alendronic Acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 66376-36-1 | |
|---|---|---|
| Molecular Formula |
C4H13NO7P2 |
|
| Molecular Weight (MW) | 249.10 | |
| SMILES | C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN |
Alendronic acid (alendronate) is a nitrogen-containing bisphosphonate that acts as an inhibitor of farnesyl pyrophosphate synthase (FPPS). By inhibiting FPPS within the mevalonate pathway, it prevents the prenylation of small GTP-binding proteins essential for osteoclast function and survival. This disruption impairs osteoclastic bone resorption and promotes osteoclast apoptosis, leading to reduced bone turnover and increased bone mineral density.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| 0.5MNAOH | 6.05 mg/mL |
| DMSO |
Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.