Print

Download

PD0325901 (Mirdametinib) SDS | MSDS

1.PRODUCT AND COMPANY IDENTIFICATION

Product identifier

  • Product Name: PD0325901 (Mirdametinib)
  • Catalog Number: S1036
  • CAS Number: 391210-10-9
  • IUPAC Name: (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide

Relevant identified uses and uses advised against

  • Identified uses: For research and development use only; laboratory chemicals; manufacture of substances.
  • Uses advised against: Not for pharmaceutical, household, or other unapproved uses.

Details of the supplier

  • Company : Selleck Chemicals
  • TollFree : +1 877 796-6397
  • Tel : +1 832 582-8158
  • Fax : +1 832 582-8590

Emergency telephone number

  • Emergency phone #: +1 832 582-8158

2. Hazard(s) identification

The substance is classified and labeled according to the Globally Harmonized System (GHS).

Classification of the substance or mixture:

  • Acute toxicity - oral 3 (H301): Toxic if swallowed.
  • Specific target organ toxicity (repeated exposure) 2 (H373): May cause damage to organs through prolonged or repeated exposure.
  • Aquatic Acute 1 (H400): Very toxic to aquatic life.
  • Aquatic Chronic 1 (H410): Very toxic to aquatic life with long lasting effects.

Label elements:
Pictogram: GHS06, GHS08, GHS09
Signal word: Danger

Hazard statements:

  • H301: Toxic if swallowed.
  • H373: May cause damage to organs through prolonged or repeated exposure.
  • H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements:

  • P260: Do not breathe dust/fume/gas/mist/vapors/spray.
  • P264: Wash thoroughly after handling.
  • P270: Do not eat, drink or smoke when using this product.
  • P273: Avoid release to the environment.
  • P301+P310: If swallowed: Immediately call a poison center/doctor.
  • P321: Specific treatment (see on this label).
  • P330: Rinse mouth.
  • P314: Get medical advice/attention if you feel unwell.
  • P391: Collect spillage.
  • P405: Store locked up.
  • P501: Dispose of contents/container in accordance with local/regional/national/international regulations.

Classification system:

  • NFPA ratings (scale 0 - 4): Health = 2, Fire = 0, Reactivity = 0.
  • HMIS-ratings (scale 0 - 4): Health = 2, Fire = 0, Reactivity = 0.

Other hazards:
Results of PBT and vPvB assessment: Not applicable.

3. Composition/information on ingredients

Chemical characterization: Substances
CAS No. Description: 391210-10-9 PD 0325901
Structural Formula: (R)-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzamide

4. First-aid measures

Description of first aid measures:

  • General information: Immediately remove any clothing soiled by the product. Symptoms of poisoning may even occur after several hours; therefore, medical observation for at least 48 hours after the accident is required. In case of irregular breathing or respiratory arrest, provide artificial respiration.
  • After inhalation: In case of unconsciousness, place patient stably in side position for transportation.
  • After skin contact: Immediately wash with water and soap and rinse thoroughly.
  • After eye contact: Rinse opened eye for several minutes under running water. Then consult a doctor.
  • After swallowing: Do not induce vomiting; immediately call for medical help.

Most important symptoms and effects, both acute and delayed: No further relevant information available.

Indication of any immediate medical attention and special treatment needed: No further relevant information available.

5. Fire-fighting measures

Extinguishing media:

  • Suitable extinguishing agents: Use fire fighting measures that suit the environment. A solid water stream may be inefficient.

Special hazards arising from the substance or mixture: No further relevant information available.

Advice for firefighters:

  • Protective equipment: No special measures required.

6. Accidental release measures

Personal precautions, protective equipment and emergency procedures: Not required.

Environmental precautions: Inform respective authorities in case of seepage into water course or sewage system. Do not allow to enter sewers/surface or ground water.

Methods and material for containment and cleaning up: Dispose contaminated material as waste according to section 13.

Protective Action Criteria for Chemicals:

  • PAC-1: Substance is not listed.
  • PAC-2: Substance is not listed.
  • PAC-3: Substance is not listed.

Reference to other sections:

  • See Section 7 for information on safe handling.
  • See Section 8 for information on personal protection equipment.
  • See Section 13 for disposal information.

7. Handling and storage

Precautions for safe handling: Thorough dedusting.
Information about protection against explosions and fires: No special measures required.

Conditions for safe storage, including any incompatibilities:

  • Storage: Store in accordance with information listed on the product insert.
  • Requirements to be met by storerooms and receptacles: No special requirements.
  • Information about storage in one common storage facility: Not required.
  • Further information about storage conditions: None.

Specific end use(s): No further relevant information available.

8. Exposure controls/personal protection

Control parameters:

  • Components with limit values that require monitoring at the workplace: Not required.
  • Additional information: The lists that were valid during the creation were used as basis.

Exposure controls:

  • Appropriate engineering controls: No further data; see section 7.
  • Personal protective equipment:
    • General protective and hygienic measures: Keep away from foodstuffs, beverages and feed. Immediately remove all soiled and contaminated clothing. Wash hands before breaks and at the end of work. Store protective clothing separately.
    • Breathing equipment: In case of brief exposure or low pollution use respiratory filter device. In case of intensive or longer exposure use respiratory protective device that is independent of circulating air.
    • Protection of hands: Protective gloves. The glove material has to be impermeable and resistant to the product/the substance/the preparation. Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation.
    • Material of gloves: The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer.
    • Penetration time of glove material: The exact break through time has to be found out by the manufacturer of the protective gloves and has to be observed.
    • Eye protection: Tightly sealed goggles.

9. Physical and chemical properties

Information on basic physical and chemical properties:

  • Physical state: powder
  • Appearance (Form): powder
  • Color: Not determined.
  • Odor: Characteristic
  • Structural Formula: C16H14F3IN2O4
  • Molecular Weight: 482.2 g/mol
  • Odor threshold: Not determined.
  • Melting point/Melting range: Undetermined.
  • Boiling point/Boiling range: Undetermined.
  • Flammability: Product is not flammable.
  • Explosion limits: Lower: Not determined; Upper: Not determined.
  • Flash point: Not applicable.
  • Decomposition temperature: Not determined.
  • pH-value: Not applicable.
  • Viscosity (Kinematic/Dynamic): Not applicable.
  • SOLUBILITY: DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 20 mg/ml
  • Water Solubility: Not determined.
  • Partition coefficient (n-octanol/water): Not determined.
  • Vapor pressure: Not applicable.
  • Density: Not determined.
  • Relative density: Not determined.
  • Vapor density: Not applicable.
  • Particle characteristics: Not determined.
  • Ignition temperature: Not determined.
  • Danger of explosion: Product does not present an explosion hazard.
  • Evaporation rate: Not applicable.

10. Stability and reactivity

Reactivity: No further relevant information available.
Chemical stability: Stable under recommended storage conditions.
Thermal decomposition / conditions to be avoided: No decomposition if used according to specifications.
Possibility of hazardous reactions: No dangerous reactions known.
Conditions to avoid: No further relevant information available.
Incompatible materials: strong oxidizing agents
Hazardous decomposition products: carbon dioxide, carbon monoxide, hydrogen fluoride, hydrogen iodide, nitrogen oxides

11. Toxicological information

Information on toxicological effects:

  • Acute toxicity: Toxic if swallowed.
  • Primary irritant effect:
    • On the skin: No irritant effect.
    • On the eye: No irritating effect.
  • Sensitization: No sensitizing effects known.
  • Interactive effects: No interactive effects between components are known.
  • Carcinogenic categories:
    • IARC (International Agency for Research on Cancer): Substance is not listed.
    • NTP (National Toxicology Program): Substance is not listed.
    • OSHA-Ca (Occupational Safety & Health Administration): Substance is not listed.

12. Ecological information

Toxicity:

  • Aquatic toxicity: No further relevant information available.
  • Remark: Very toxic for fish.

Persistence and degradability: No further relevant information available.
Bioaccumulative potential: No further relevant information available.
Mobility in soil: No further relevant information available.

Results of PBT and vPvB assessment:

  • PBT: Not applicable.
  • vPvB: Not applicable.

Other adverse effects:

  • General notes: Water hazard class 3 (Self-assessment): extremely hazardous for water. Do not allow product to reach ground water, water course or sewage system, even in small quantities. Danger to drinking water if even extremely small quantities leak into the ground. Also poisonous for fish and plankton in water bodies. Very toxic for aquatic organisms.

13. Disposal considerations

Waste treatment methods:

  • Recommendation: Must not be disposed of together with household garbage. Do not allow product to reach sewage system.

Uncleaned packagings:

  • Recommendation: Disposal must be made according to official regulations.

14. Transport information

UN-Number:

  • DOT, IMDG, IATA: UN2811

UN proper shipping name:

  • DOT: Toxic solids, organic, n.o.s. (PD 0325901)
  • IMDG: TOXIC SOLID, ORGANIC, N.O.S. (PD 0325901)
  • IATA: Toxic solid, organic, n.o.s. (PD 0325901)

Transport hazard class(es):

  • DOT, IMDG, IATA Class: 6.1 Toxic substances
  • Label: 6.1

Packing group:

  • DOT, IMDG, IATA: III

Environmental hazards:

  • Marine pollutant: Symbol (fish and tree)
  • General: Environmentally hazardous substance, powder

Special precautions for user: Warning: Toxic substances

  • Hazard identification number (Kemler code): 60
  • EMS Number: F-A, S-A
  • Stowage Category: A

Transport in bulk according to Annex II of MARPOL73/78 and the IBC Code: Not applicable.

Transport/Additional information:

  • DOT Quantity limitations: On passenger aircraft/rail: 100 kg; On cargo aircraft only: 200 kg
  • IMDG Limited quantities (LQ): 5 kg
  • IMDG Excepted quantities (EQ): Code: E1 (Maximum net quantity per inner packaging: 30 g; Maximum net quantity per outer packaging: 1000 g)
  • IATA Remarks: When sold in quantities of less than or equal to 1 mL, or 1 g, with an Excepted Quantity Code of E1, E2, E4, or E5, this item meets the De Minimis Quantities exemption, per IATA 2.6.10. Therefore packaging does not have to be labeled as Dangerous Goods/Excepted Quantity.

UN "Model Regulation": UN 2811 TOXIC SOLID, ORGANIC, N.O.S. (PD 0325901), 6.1, III, ENVIRONMENTALLY HAZARDOUS

15. Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture:
No further relevant information available.

Sara:

  • Section 355 (extremely hazardous substances): Substance is not listed.
  • Section 313 (Specific toxic chemical listings): Substance is not listed.

TSCA (Toxic Substances Control Act): Substance is not listed.
Hazardous Air Pollutants: Substance is not listed.

California Proposition 65:

  • Chemicals known to cause cancer: Substance is not listed.
  • Chemicals known to cause reproductive toxicity for females: Substance is not listed.
  • Chemicals known to cause reproductive toxicity for males: Substance is not listed.
  • Chemicals known to cause developmental toxicity: Substance is not listed.

Carcinogenic categories:

  • EPA (Environmental Protection Agency): Substance is not listed.
  • TLV (Threshold Limit Value): Substance is not listed.
  • NIOSH-Ca (National Institute for Occupational Safety and Health): Substance is not listed.

Chemical safety assessment: A Chemical Safety Assessment has not been carried out.

16. OTHER INFORMATION

Revision Date: 2026/07/09
Further Information: The information provided is believed to be correct but is not exhaustive and should be used only as a guideline based on current knowledge. It does not represent a guarantee of the properties of the product. Selleck Chemicals Corporation and its Affiliates shall not be held liable for any damage resulting from handling or contact with the product.

Jump to: