CAS No. 391210-10-9
Batch:
Purity:99.99
Chemical Structure
Check the
PD0325901 (Mirdametinib)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide | |
|---|---|---|
| CAS Number | 391210-10-9 | |
| Molecular Formula |
C16H14F3IN2O4 |
|
| Molecular Weight (MW) | 482.19 | |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC(=C2F)F)C(=O)NOCC(CO)O | |
| InChIKey | SUDAHWBOROXANE-SECBINFHSA-N |
PD0325901 (Mirdametinib) is a selective, non-ATP-competitive MEK inhibitor targeting MEK1 and MEK2. By inhibiting MEK activity, it blocks downstream phosphorylation of ERK1 and ERK2, thereby suppressing the MAPK/ERK signaling pathway. This inhibition impairs tumor cell proliferation and survival across various cancer models. Furthermore, PD0325901 demonstrates potent antitumor efficacy and growth suppression in preclinical tumor models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 96 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- PD0325901 (Mirdametinib) Mechanism of Action: MEK1/2 Inhibition in Schwann Cells Research
- PD0325901 (Mirdametinib) Clinical Trials
- PD0325901 (Mirdametinib): Selectivity & Specificity
- PD0325901 (Mirdametinib) Working Concentration | Cell Culture | Treatment
- PD0325901 (Mirdametinib) Solubility in DMSO
- PD0325901 (Mirdametinib) Stock Solution
- PD0325901 (Mirdametinib) Storage
- PD0325901 (Mirdametinib) Stability
- PD0325901 (Mirdametinib) Combination Database
- PD0325901 (Mirdametinib) Molecular Weight
- PD0325901 (Mirdametinib) SMILES
- PD0325901 (Mirdametinib) Chemical Structure (2D and 3D)
- PD0325901 (Mirdametinib) IC50 for Cell-based and Cell-free Assays
- PD0325901 (Mirdametinib) MedChemExpress (HY-10254)? Try a better option.
- PD0325901 (Mirdametinib) Cayman (13034)? Try a better option.
- PD0325901 (Mirdametinib) Abmole (M1763)? Try a better option.
- PD0325901 (Mirdametinib) STEMCELL (72184)? Try a better option.
- PD0325901 (Mirdametinib) Sigma (PZ0162)? Try a better option.
- PD0325901 (Mirdametinib) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.