CAS No. 1211877-36-9
| IUPAC Name | benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate | |
|---|---|---|
| CAS Number | 1211877-36-9 | |
| Molecular Formula |
C26H41N3O5 |
|
| Molecular Weight (MW) | 475.62 | |
| SMILES | CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1 | |
| InChIKey | TZYWCYJVHRLUCT-ZRBLBEILSA-N |
MG132 is a potent, cell-permeable peptide aldehyde inhibitor of the proteasome and calpain. It blocks the 26S proteasome complex to prevent the degradation of ubiquitin-conjugated proteins. By inhibiting proteasomal degradation, MG132 blocks TNF-alpha-induced NF-kB activation and IkB-alpha degradation. Additionally, MG132 activates c-Jun N-terminal kinase (JNK1) signaling to trigger apoptosis and induces neurite outgrowth in PC12 cells, demonstrating robust anticancer activity in vitro. [1][2]
|
Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
| DMSO |
95 mg/mL
(199.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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- MG132 Mechanism of Action: Proteasome Inhibition in Tumor Cell Research
- MG132: Selectivity & Specificity
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- MG132 Solubility in DMSO
- MG132 Stock Solution
- MG132 Storage
- MG132 Stability
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- MG132 Molecular Weight
- MG132 SMILES
- MG132 Chemical Structure (2D and 3D)
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