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L-Ascorbyl 6-palmitate

Name: L-Ascorbyl 6-palmitate
Brand: Selleck Chemicals
SKU: S2532
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S2532

L-Ascorbyl 6-palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat-soluble form of vitamin C.

Chemical Structure

Molecular Weight: 414.53

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Quality Control

Batch: S253201 DMSO]83 mg/mL]false]Ethanol]83 mg/mL]false]Water]Insoluble]false Purity: 100%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

100

Related Targets	PROTAC Dyes Antineoplastic and Immunosuppressive Antibiotics ADC Cytotoxin Selection Antibiotics for Transfected Cell Antibiotics for Mammalian Cell Culture ADC Linker Molecular Glues Hydrotropic Agents Antibiotics for Plant Cell Culture
Other Others Inhibitors	Furimazine (PBI 3939) BAY 2927088（Sevabertinib） Guanidinoacetic acid BAPTA-AM Blebbistatin Silibinin (NSC 651520) Polybrene (Hexadimethrine Bromide) Carbazochrome sodium sulfonate (AC-17) Palmitic acid Osthole

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (200.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	414.53	Formula	C₂₂H₃₈O₇	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	137-66-6	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O

Mechanism of Action

In vitro	L-Ascorbyl 6-palmitate is a synthetic lipophilic ascorbic acid derivative. This compound is an effective preservative in foods and an effective dietary antitumor promoter in mice. Studies indicate that dietary this chemical is a source of tissue vitamin C in animals. Besides, dietary it possesses weak antiscorbutic activity in guinea pigs and enhances vitamin C nutriture in humans.
In vivo	In a study, daily mean weight loss during repletion in control animals receiving placebo is significantly greater than that for L-Ascorbyl 6-palmitate animals for days 3–10 of repletion. Daily mean weight loss for this compound animals is significantly greater than that for L-ascorbic acid (AA) animals on days 5 and 6 of repletion. By comparing areas of the weight-time curve during repletion, this compound appeares to be about 50% as effective as L-ascorbic acid (AA) in reversing scurvy.
References	[1] http://www.sciencedirect.com/science/article/pii/S027153170580226X [2] https://pubmed.ncbi.nlm.nih.gov/3188040/

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