Catalog No.S1507 Synonyms: BMS-186295, SR-47436

For research use only.

Irbesartan (BMS-186295, SR-47436) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

Irbesartan Chemical Structure

CAS No. 138402-11-6

Selleck's Irbesartan has been cited by 5 Publications

2 Customer Reviews

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Choose Selective Angiotensin Receptor Inhibitors

Biological Activity

Description Irbesartan (BMS-186295, SR-47436) is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.
Features Irbesartan is a longer acting AT1 receptor antagonist relative to losartan and valsartan.
AT1 receptor [1]
1.3 nM
In vitro

Irbesartan competes with angiotensin II (AII) for binding at the AT1 receptor subtype and antagonizes AII-induced contraction in rabbit aorta ring with IC50 of 4 nM. Irbesartan has no affinity for AT2 receptors. [1] Irbesartan (10 μM) blocks angiotensin II induced increase in αv, β1, β3, and β5 integrins, osteopontin, and α-actinin mRNA and protein levels in rat cardiac fibroblasts, leading to the decrease of cell attachment to extracellular matrix (ECM) proteins. [2] Irbesartan treatment markedly induces the expression of the adipogenic marker gene adipose protein 2 (aP2) in 3T3-L1 cells in a concentration-dependent manner with EC50 of 3.5 μM and 3.3-fold induction at the concentration of 10 μM. Irbesartan (10 μM) markedly induces transcriptional activity of the peroxisome proliferator–activated receptor-γ (PPARγ) by 3.4-fold independent of its AT1 receptor blocking action. [3] Pretreatment with Irbesartan (~10 μM) decreases angiotensin II-induced apoptosis in rat vascular smooth muscle cells by blocking angiotensin II internalization in a concentrationdependent manner. [4]

In vivo Oral administration of Irbesartan (1 mg/kg) reduces angiotensin II (AII)-induced hypertension, equipotent with losartan in conscious normotensive rats, markedly more active than losartan (10 mg/kg) in normotensive cynomolgus monkeys. [1] Administration of Irbesartan (7 mg/kg/day) significantly prevents skeletal muscle apoptosis and muscle atrophy in rats with monocrotaline-induced congestive heart failure (CHF), which is involved with the decrease of TNFα level and attributed to AT1 receptor blocking. [5]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Male Sprague-Dawley rats and female cynomolgus monkeys (Macaca fascicularis) injected (iv) with angiotensin II (AII)
  • Dosages: 1 mg/kg
  • Administration: Oral gavage

Solubility (25°C)

In vitro

DMSO 4 mg/mL warmed
(9.33 mM)
Ethanol 3 mg/mL
(7.0 mM)
Water Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
30% PEG400+0.5% Tween80+5% propylene glycol
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 428.53


CAS No. 138402-11-6
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04983979 Not yet recruiting Drug: Sodium Zirconium Cyclosilicate|Drug: Placebo CKD|Diabetes Mellitus Type 2|Hyperkalemia Barts & The London NHS Trust August 15 2021 Phase 2
NCT03627715 Active not recruiting Drug: Propagermanium|Drug: Placebo Diabetic Kidney Disease Dimerix Bioscience Pty Ltd|Iqvia Pty Ltd November 6 2018 Phase 2
NCT03649152 Active not recruiting Drug: Propagermanium|Drug: Placebo Focal Segmental Glomerulosclerosis Dimerix Bioscience Pty Ltd|Iqvia Pty Ltd November 8 2018 Phase 2
NCT03476603 Recruiting Drug: Irbesartan Obesity Morbid Norwegian University of Science and Technology|St. Olavs Hospital|Volvat Medisinsk Senter Stokkan|Namsos Hospital|Alesund Hospital November 2 2016 --
NCT02597361 Completed Drug: Irbesartan|Drug: Placebo Ehlers-Danlos Syndrome Vascular Type Assistance Publique - Hôpitaux de Paris|Ministry of Health France January 2016 Phase 3

(data from, updated on 2022-01-17)

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