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Divalproex Sodium HDAC inhibitor

Cat.No.S1703

Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
Divalproex Sodium HDAC inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 310.41

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Quality Control

Batch: S170301 DMSO]62 mg/mL]false]Water]62 mg/mL]false]Ethanol]62 mg/mL]false Purity: 99.91%
99.91

Chemical Information, Storage & Stability

Molecular Weight 310.41 Formula

C8H16O2.C8H15O2.Na

 Storage (From the date of receipt)
CAS No. 76584-70-8 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]

Solubility

In vitro
Batch:

DMSO : 62 mg/mL ( (199.73 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 62 mg/mL

Ethanol : 62 mg/mL

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC50/Ki
HDAC [1]
In vitro
Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. [1] Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC. [2]
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01094249 Completed
Schizophrenia|Bipolar Disorder|Psychotic Disorders
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
 February 2009 Phase 1
NCT01060228 Completed
Schizophrenia|Epilepsy
Johnson & Johnson Pharmaceutical Research & Development L.L.C.
 January 2009 Phase 1
NCT01055938 Completed
Healthy
Dr. Reddy''s Laboratories Limited
 December 2006 Phase 1
NCT01056627 Completed
Healthy
Dr. Reddy''s Laboratories Limited
 December 2006 Phase 1

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