Divalproex Sodium

Catalog No.S1703

For research use only.

Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

Divalproex Sodium Chemical Structure

CAS No. 76584-70-8

Selleck's Divalproex Sodium has been cited by 1 Publication

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Purity & Quality Control

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Biological Activity

Description Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
Targets
HDAC [1]
In vitro

Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. [1] Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC. [2]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 310.41
Formula

C8H16O2.C8H15O2.Na

CAS No. 76584-70-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCC(CCC)C(=O)O.CCCC(CCC)C(=O)[O-].[Na+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01094249 Completed Drug: divalproex sodium ER/paliperidone ER Schizophrenia|Bipolar Disorder|Psychotic Disorders Johnson & Johnson Pharmaceutical Research & Development L.L.C. February 2009 Phase 1
NCT01060228 Completed Drug: paliperidone ER|Drug: divalproex sodium ER Schizophrenia|Epilepsy Johnson & Johnson Pharmaceutical Research & Development L.L.C. January 2009 Phase 1
NCT01055938 Completed Drug: Divalproex Sodium Healthy Dr. Reddy''s Laboratories Limited December 2006 Phase 1
NCT01056627 Completed Drug: Divalproex Sodium Healthy Dr. Reddy''s Laboratories Limited December 2006 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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