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CAS No. 76584-70-8
Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
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Divalproex sodium increases the level of acetylated histone H3 level in ataxin-3-transfected HEK293 cells. Normal (15CAG) or expanded (77CAG) ataxin-3-transfected cells were treated with divalproex sodium (Selleck chemical, 0.3 mmol/L in DMSO, (+)) or with DMSO alone (−) 48 h after transfection. The cells were treated with divalproex sodium or DMSO over 6, 12, and 24 h. The Western blot was probed with antiacetylated histone H3, antihistone H3, and antiataxin-3. Antibodies include antihistone H3 and antiataxin-3 are used as controls. The x-axis shows the different treatment group. The y-axis represents the acetylated histone H3 values normalized to histone H3. Error bars represent the standard error of the mean. Data represent three independent experiments (n = 3). The data with a normal distribution were analyzed with Student’s t-test. *P < 0.05
CNS Neurosci Ther, 2018, 24(5):404-411. Divalproex Sodium purchased from Selleck.
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|Description||Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.|
Divalproex sodium enhances IM-induced cell growth inhibition, apoptosis and cell cycle arrest in K562-S and K562-G cells. Divalproex sodium enhances the inhibitory effects of IM on SIRT1 expression in K562-S and K562-G cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1.  Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas a lower dose of Divalproex, 50 mg/kg, has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC. 
|In vitro||DMSO||62 mg/mL (199.73 mM)|
|Water||62 mg/mL (199.73 mM)|
|Ethanol||62 mg/mL (199.73 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01094249||Completed||Drug: divalproex sodium ER/paliperidone ER||Schizophrenia|Bipolar Disorder|Psychotic Disorders||Johnson & Johnson Pharmaceutical Research & Development L.L.C.||February 2009||Phase 1|
|NCT01060228||Completed||Drug: paliperidone ER|Drug: divalproex sodium ER||Schizophrenia|Epilepsy||Johnson & Johnson Pharmaceutical Research & Development L.L.C.||January 2009||Phase 1|
|NCT01055938||Completed||Drug: Divalproex Sodium||Healthy||Dr. Reddy''s Laboratories Limited||December 2006||Phase 1|
|NCT01056627||Completed||Drug: Divalproex Sodium||Healthy||Dr. Reddy''s Laboratories Limited||December 2006||Phase 1|
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