Catalog No.S1500 Synonyms: NSC-39470, SCH-4831

For research use only.

Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Betamethasone  Chemical Structure

CAS No. 378-44-9

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Biological Activity

Description Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
Glucocorticoid receptor [1]
In vitro

Betamethasone has a specific affinity for type II glucocorticoid receptors which are present in most brain regions. [1]

In vivo Betamethasone has direct vasoconstrictor effects on peripheral femoral resistance vessels in late gestation fetal sheep. Betamethasone exposure decreases cerebral blood flow (CBF) in all brain regions measured except the hippocampus after 24 hours of infusion in sheep. [1] Betamethasone reduces the activation of NF-kappaB and elevation of TNFalpha and IL-1beta, and induces the expression of IL-10 in the brain, all of which correlate with the changes of pain thresholds in rats. [2] Betamethasone exposure reduces synaptophysin-LI in the frontal neocortex, caudate putamen and hippocampus by 46.9%, 41.0% and 55.4%, respectively, that is not accompanied by irreversible neuronal damage in the fetal sheep brain. [3] Betamethasone modestly increases cytidylyltransferase (CT) mRNA, but does not alter the levels of immunoreactive enzyme in adult rat lung. Betamethasone decreases the activities of the sphingomyelin hydrolases: acid sphingomyelinase by 33% and of alkaline ceramidase by 21%. [4] Betamethasone injected at the time of nerve injury partially inhibits the development of neuropathic hyperalgesia and reduces the subsequent elevated levels of pro-inflammatory cytokines in the brain of rats, while stimulating the expression of the anti-inflammatory cytokine IL-10. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 392.46


CAS No. 378-44-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04770805 Recruiting Procedure: Fetoscopy Sacral Myelomeningocele|Neural Tube Defects|Spina Bifida Assistance Publique - Hôpitaux de Paris April 16 2021 Not Applicable
NCT03210545 Recruiting Drug: Betamethasone Addison Disease Göteborg University March 2 2021 Phase 4
NCT04645979 Completed Other: Online survey Rhinitis Allergic Bayer November 11 2020 --
NCT04492072 Recruiting Drug: Oxytocin|Drug: Misoprostol Cesarean Section|Misoprostol|Oxytocin|High Risk Pregnancy Thomas Jefferson University August 17 2020 Not Applicable

(data from, updated on 2022-01-17)

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