3,4-Diaminopyridine

Catalog No.S4622 Synonyms: Amifampridine, pyridine-3,4-diamine

For research use only.

3,4-Diaminopyridine (Amifampridine, pyridine-3,4-diamine) blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases.

3,4-Diaminopyridine Chemical Structure

CAS No. 54-96-6

Purity & Quality Control

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Biological Activity

Description 3,4-Diaminopyridine (Amifampridine, pyridine-3,4-diamine) blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 22 mg/mL
(201.59 mM)
Ethanol 22 mg/mL
(201.59 mM)
Water 7 mg/mL
(64.14 mM)

Chemical Information

Molecular Weight 109.13
Formula

C5H7N3

CAS No. 54-96-6
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CN=CC(=C1N)N

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Molarity Calculator

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