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(R,S)-3,5-DHPG Hydrochloride GluR chemical

Cat.No.E1257

(R,S)-3,5-DHPG hydrochloride (DHPG, Dihydroxy phenylglycine) is a salt of free amino acid dihydroxy phenylglycine (DHPG) which acts as a selective and potent agonist of group I metabotropic glutamate receptors (mGluR) (mGluR 1 and mGluR 5).
(R,S)-3,5-DHPG Hydrochloride GluR chemical Chemical Structure

Chemical Structure

Molecular Weight: 219.62

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Quality Control

Batch: E125701 DMSO]44 mg/mL]false]Water]44 mg/mL]false]Ethanol]22 mg/mL]false Purity: 99.07%
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99.07

Solubility

In vitro
Batch:

DMSO : 44 mg/mL (200.34 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 44 mg/mL

Ethanol : 22 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 219.62 Formula

C8H9NO4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 19641-83-9 -- Storage of Stock Solutions

Synonyms DHPG, Dihydroxy phenylglycine Smiles Cl.NC(C(O)=O)C1=CC(=CC(=C1)O)O

Mechanism of Action

Targets/IC50/Ki
mGluR
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03154359 Completed
ADHD
Children''s Mercy Hospital Kansas City|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
 December 12 2017 --
NCT02428088 Completed
Attention Deficit Hyperactivity Disorder
Sumitomo Pharma America Inc.
 April 2015 Phase 2|Phase 3

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