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Insulin (human)

Catalog No.S6955 Purity: 99.99%

Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.

Amino-acid Sequence

CAS No. 11061-68-0

Selleck's Insulin (human) Has Been Cited by 10 Publications

Purity & Quality Control

Batch: Purity: 99.99%

99.99

Chemical Information & Solubility

Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

0.01M HCl : 13 mg/mL

Water : Insoluble

Ethanol : Insoluble

Molecular Weight Calculator

In vivo Batch: Add solvents to the product individually and in order.					In vivo Formulation Calculator
	Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.	In vivo Formulation Calculator
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	2.500mg/ml (0.43mM)	Taking the 1 mL working solution as an example, add 50 μL of 50 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	0.400mg/ml (0.07mM)	Taking the 1 mL working solution as an example, add 50 μL of 8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

Biological Activity

Description	Insulin (human) (Insulin regular) is a polypeptide hormone that regulates the level of glucose. Insulin is commonly used to treat hyperglycemia in patients with diabetes. Potency: 29 units/mg.

In vitro
In vitro	Insulin, an inducer of AKT phosphorylation, reduces the levels of LC3-II, VP1 by the AKT-AMPKMAPK-MTOR pathway in SVV-infected cells.^[2]
Cell Research	Cell lines	BHK-21 cells and PK-15 cells
	Concentrations	200 ng/ml
	Incubation Time	1 h
	Method	BHK-21 cells and PK-15 cells are grown to 80% confluence in well plates and pretreated with insulin (200 ng/ml) for 1 h. The pretreated cells are then infected with SVV for 1 h. The cells are then washed with phosphate-buffered saline (PBS) and incubated with new medium containing the same chemical reagents. Cell viability in the presence of chemical reagents is tested.

References
https://pubmed.ncbi.nlm.nih.gov/26537234/ https://pubmed.ncbi.nlm.nih.gov/34757844/

References

https://pubmed.ncbi.nlm.nih.gov/26537234/
https://pubmed.ncbi.nlm.nih.gov/34757844/

Product Information

Molecular Formula:	C₂₅₇H₃₈₃N₆₅O₇₇S₆
Molecular Weight:	5807.57
CAS No.:	11061-68-0
Storage (From the date of receipt):	3 years -20°C powder
Shipping:	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)