p53 Activators

Cat.No.	Product Name	Information	Product Use Citations
S7724	Eprenetapopt (APR-246)	Eprenetapopt (APR-246, PRIMA-1MET) is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types. It induces apoptosis and autophagy.	Oncotarget, 2024, 15:614-633 J Cell Mol Med, 2024, 28(9):e18374 Cell Death Dis, 2023, 14(11):783
S2781	RITA	RITA induces both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks, and this compound also inhibits MDM2-p53 interaction by targeting p53.	PLOS ONE, 2026, e0343551 Cell Death Discov, 2024, 10(1):381 J Cancer, 2023, 14(2):200-218
S1172	Serdemetan (JNJ-26854165)	Serdemetan (JNJ-26854165) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. Phase 1.	Elife, 2025, 14e75393 J Physiol, 2025, 603(19):5477-5508 Signal Transduct Target Ther, 2022, 7(1):97
S8483	CBL0137 Hydrochloride	CBL0137 (CBLC137, Curaxin 137) HCl activates p53 and inhibits NF-κB with EC50s of 0.37 μM and 0.47 μM in the cell-based p53 and NF-kB reporter assays, respectively. It also inhibits histone chaperone FACT (facilitates chromatin transcription complex).	Oncogene, 2025, 893-908 Oncogene, 2025, 44(13):893-908 Cancer Biology & Therapy, 2025, 2511301
S7149	NSC 319726 (ZMC1)	NSC 319726 (ZMC1) is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells.	Cell Rep Med, 2025, S2666-3791(25)00102-8 Cell Reports Medicine, 2025, 102029 iScience, 2022, 105182
S7723	PRIMA-1	PRIMA-1 (2,2-Bis(hydroxymethyl)-3-quinuclidinone) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.	Journal of Controlled Release, 2024, 111-125 J Control Release, 2024, 371:111-125 Nat Chem Biol, 2022, 10.1038/s41589-022-00996-7
S8000	Tenovin-1	Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. This compound is also an inhibitor of dihydroorotate dehydrogenase (DHODH).	American Journal of Physiology-Renal Physiology, March 1, 2024, F326-F337 Oncotarget, July 11, 2017, 100691-100707 American Journal of Physiology-Renal Physiology, 2024, F326-F337
S8106	NSC59984	NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.	Micromachines, 2026, 276 Micromachines, 2026, 276 Cancers (Basel), 2023, 15(3)745
S8149	NSC348884	NSC348884, as a nucleophosmin inhibitor, inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.	Mol Cell, 2025, S1097-2765(25)00409-5 Front Immunol, 2022, 13:956991 Nat Commun, 2020, 3;11(1):1669
S4900	Tenovin-6	Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). This compound is also an inhibitor of SirT1 and SirT2.	Cell Death Dis, 2023, 14(10):667 Front Immunol, 2021, 12:685523 Biomed Pharmacother, 2020, 125:109948
S8580	COTI-2	COTI-2 is an orally available third generation thiosemicarbazone and activator of mutant forms of the p53 protein, with potential antineoplastic activity.	Biometals, 2025, 10.1007/s10534-025-00736-z J Cell Mol Med, 2024, 28(9):e18374 DASH, 2020, None
S5811	Kevetrin hydrochloride	Kevetrin hydrochloride (Thioureidobutyronitrile) is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.	International Journal of Molecular Sciences, September 02, 2022, 10042 International Journal of Molecular Sciences, 2022, 10042 Int J Mol Sci, 2022, 23(17)10042
E1971	Rezatapopt	Rezatapopt(PC14586) is a first-in-class p53 reactivator. It selectively binds to the mutated p53 Y220C protein and restores its wild-type activity. It can also be used to inhibit solid tumor with p53 mutation.
E7154	C16-Ceramide	C16-Ceramide (N-Palmitoylsphingosine)is a sphingolipid ligand and an activator of p53 tumor suppressor. It tightly binds within the p53 DNA-binding domain with a Kd of ~ 60 nM, in close vicinity to the Box V motif. It regulates the protein ubiquitination and proteasomal degradation and also induces apoptosis in cancer cells making it a research tool for targeting human cancers.
S2427	Triglycidyl Isocyanurate (Teroxirone)	Triglycidyl Isocyanurate (Teroxirone, Tris(2,3-epoxypropyl) Isocyanurate, TGI, TGIC) is a triazene triepoxide with antineoplastic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. This compound alkylates and cross-links DNA, thereby inhibiting DNA replication. It is also used in various polyester powder coatings in the metal finishing industry.
S8059	Nutlin-3a	Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay. Nutlin-3a induces autophagy and apoptosis in a p53-dependent manner.	Nucleic Acids Res, 2025, 53(13)gkaf627 Cell Rep Med, 2025, 6(8):102284 Bone Res, 2025, 13(1):62
S2341	(-)-Parthenolide	(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.	J Adv Res, 2025, S2090-1232(25)00353-4 Biomed Pharmacother, 2025, 188:118183 Cell Death Discov, 2025, 11(1):286
S7649	SAR405838	SAR405838 is an orally available MDM2 antagonist with K_i of 0.88 nM. This compound is a diastereomer of MI-773 (CAS: 1303607-07-9). Phase 1.	Nat Genet, 2025, 57(1):140-153 Pharmaceutics, 2023, 15(4)1274 bioRxiv, 2023, 10.1101/2023.03.10.531074
S0507	CBL0137	CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.	Oncology Reports, March 24 2022, 99 Cells, June 08 2020, 1423 Oncogene, 2024, 893-908
S2678	NSC 207895	NSC 207895 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.	Oncotarget, November 17, 2020, 4224-4242 PLoS One, January 26, 2024, e0295629 PLoS One, 2024, e0295629
S2176	Tenovin-3	Tenovin-3 is an inhibitor of SIRT2. This compound is able to increase p53 levels in MCF-7 cells.	Frontiers in Pharmacology, 2022, 903235
E3037	Solanum lyratum Extract	Solanum lyratum Extract (300 μg/ml) increases Bax levels and decreases Bcl-2 levels, which cause the loss of mitochondrial membrane potential (Δæm) followed by cytochrome C release and caspase-9 and -3 activation, finally leading to apoptosis. This compound also promotes p53 and p27, but decreases the levels of cyclin B1 thus causing S-phase arrest.