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p53 Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S2929 Pifithrin-α (PFTα) Hhydrobromide Pifithrin-α is an inhibitor of p53, inhibiting p53-dependent transactivation of p53-responsive genes. Pifithrin-α is also a potent agonist of the aryl hydrocarbon receptor (AhR).
J Adv Res, 2025, S2090-1232(25)00192-4
Front Pharmacol, 2025, 16:1608156
J Cell Mol Med, 2025, 29(11):e70641
Verified customer review of Pifithrin-α (PFTα) Hhydrobromide
S2930 Pifithrin-μ Pifithrin-μ (NSC 303580, PFTμ, 2-Phenylethynesulfonamide) is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and this compound also inhibits HSP70 function and autophagy.
Cell Death Dis, 2025, 16(1):42
Front Nutr, 2025, 12:1663245
Sci Adv, 2025, 11(12):eadq9111
Verified customer review of Pifithrin-μ
S5791 Cyclic Pifithrin-α hydrobromide Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53.
Front Pharmacol, 2022, 13:926317
Frontiers in Pharmacology, 2022, 926317
Clinical and Translational Medicine, 2020, e41
S8187 ReACp53 ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC).
PNAS Nexus, 2022, pgac128
PNAS Nexus, 2022, 1(3):pgac128
Nature Communications, 2021, 3962
E2943 Pifithrin-β Pifithrin-β (PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide) is a potent inhibitor of p53 with an IC50 of 23 μM and is regarded as a lead compound for cancer and neurodegenerative disease therapy.
Biol Reprod, 2025, ioaf113
Biology of Reproduction, 2025, 777-786
S9235 Didymin Didymin (Neoponcirin, Isosakuranetin-7-O-rutinoside) is a citrus-derived natural compound that kills p53 wild-type as well as drug-resistant p53-mutant neuroblastoma cells in culture. It possesses antioxidant, anti-inflammation and anti-cancer properties.
E0935 MS7972 MS7972 is a small molecule that blocks human p53 and CREB binding protein association.
E1735 PK11007 PK11007 is a thiol-reactive anticancer agent that stabilizes p53 via selective alkylation of two surface cysteines without compromising its DNA binding. It induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels.
S9488 Lobetyolin Lobetyolin is one of the important active ingredients extracted from the root of Codonopsis pilosula, which has a good protective effect on gastric mucosal damage. This compound can downregulate glutamine metabolism, contribute to drug-induced apoptosis and tumor growth inhibition, and it significantly reduces the mRNA and protein expression of the amino acid transporter alanine-serine-cysteine ​​transporter 2 (ASCT2).
S7030 RG-7112 RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.
NPJ Aging, 2025, 11(1):6
Int J Mol Sci, 2024, 25(7)3948
bioRxiv, 2024, 2024.10.09.617493
E0068 NiCur NiCur is a small molecule which blocks CREB-binding protein (CBP) histone acetyltransferase (HAT) activity and downregulates p53 activation upon genotoxic stress and diminishs the recruitment of p53 as well as RNA Polymerase II and levels of acetylation on histone H3 on CDKN1A promoter.
E0394 YK 3-237 YK-3-237, a SIRT1 activator, reduces acetylation of mutant p53 and inhibits the proliferation of triple-negative breast cancer cells.