For research use only.
Catalog No.S9693 Synonyms: BAY1021189, Verquvo
CAS No. 1350653-20-1
Vericiguat (BAY1021189, Verquvo) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.
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|Description||Vericiguat (BAY1021189, Verquvo) is a potent, orally available and soluble guanylate cyclase (sGC) stimulator.|
The stimulation of sGC by Vericiguat is examined with a recombinant CHO cell line overexpressing rat sGC. Vericiguat stimulates the sGC reporter cell line concentration dependently with an EC50 of 1005 ± 145 nM. In the presence of the NO donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP) (30 and 100 nM), the EC50 value shifts to 39.0 ± 5.1 and 10.6 ± 1.7 nM, respectively. In the presence of ODQ, pretreatment of the sGC reporter cell line with 10 μM ODQ for 3 h results in a significantly reduced efficacy of Vericiguat, with an EC50 of 256 ± 40 nM being observed.
Vericiguat can maintain heart and kidney function in a model of hypertension-induced end-organ damage with substantially reduced overall mortality.
|In vitro||DMSO||85 mg/mL (199.35 mM)|
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|Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)|
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT04722562||Completed||Drug: Vericiguat (BAY1021189)||Heart Failure||Bayer|Merck Sharp & Dohme Corp.||July 16 2014||Phase 1|
|NCT04722484||Completed||Drug: Vericiguat (BAY1021189)||Heart Failure||Bayer|Merck Sharp & Dohme Corp.||June 12 2014||Phase 1|
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