Acetyl-CoA carboxylase

All (5) Acetyl-CoA carboxylase Inhibitors (5)

Catalog No.	Information	Product Use Citations
S8893	Firsocostat (GS-0976) Firsocostat (GS-0976, NDI-010976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively.
S6672	PF-05175157 PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively.
S8377^New	ND646 In cell-free systems, ND-646 inhibits the enzymatic activity of recombinant human ACC1 (hACC1) and recombinant hACC2 with IC50 of 3.5 nM and 4.1 nM, respectively.
S6690	TOFA (5-(Tetradecyloxy)-2-furoic acid) TOFA (5-(Tetradecyloxy)-2-furoic acid, Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). Inside the cell, TOFA is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner.
S6753	CP 640186 CP 640186 is an isozyme-nonselective ACC (Acetyl-CoA carboxylase) inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.	Exp Ther Med, 2020, 20(1):521-529 Molecules, 2015, 20(9):16221-34 Molecules, 2015, 20(9):16221-34

Catalog No.	Information	Product Use Citations
S8893	Firsocostat (GS-0976) Firsocostat (GS-0976, NDI-010976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively.
S6672	PF-05175157 PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively.
S8377^New	ND646 In cell-free systems, ND-646 inhibits the enzymatic activity of recombinant human ACC1 (hACC1) and recombinant hACC2 with IC50 of 3.5 nM and 4.1 nM, respectively.
S6690	TOFA (5-(Tetradecyloxy)-2-furoic acid) TOFA (5-(Tetradecyloxy)-2-furoic acid, Tyrphostin 46,Tyrphostin A46,Tyrphostin B40) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). Inside the cell, TOFA is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner.
S6753	CP 640186 CP 640186 is an isozyme-nonselective ACC (Acetyl-CoA carboxylase) inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.	Exp Ther Med, 2020, 20(1):521-529 Molecules, 2015, 20(9):16221-34 Molecules, 2015, 20(9):16221-34