Home Microbiology Bacterial inhibitor Tulathromycin A For research use only.

Tulathromycin A

Tulathromycin A is a novel long-acting semi-synthetic tribasic macrocyclic antibiotic of the triamilide group and used for the treatment of pulmonary diseases of swine and cattle.

Tulathromycin A Chemical Structure

Tulathromycin A Chemical Structure

CAS: 217500-96-4

Purity & Quality Control

Batch: S371201 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] Water] Insoluble] false Purity: 98.88%
98.88

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Biological Activity

Description Tulathromycin A is a novel long-acting semi-synthetic tribasic macrocyclic antibiotic of the triamilide group and used for the treatment of pulmonary diseases of swine and cattle.
In vitro
In vitro Tulathromycin A is a macrolide antibiotic that inhibits bacterial protein synthesis (IC50 = 0.26 µM) by targeting the 50S ribosomal subunit, blocking the progression of nascent polypeptide chains[2].
In Vivo
In vivo In cattle and swine, tulathromycin is characterized by a rapid rate of absorption and large systemic availability after subcutaneous (s.c.) and intramuscular (i.m.) administration. In contrast, oral administration of tulathromycin, using a compounded formulation, has a lower systemic availability (~50%). In plasma, tulathromycin has a long terminal half-life, ranging across species from ~2 to ~5 days except in mice in which the terminal half-life is <20 h. The longest terminal half-life in plasma is seen in foals (~140 h). Lung pharmacokinetic studies in cattle, pigs, horses, and mice show that tulathromycin accumulates in lung tissue. In general, tulathromycin is absorbed rapidly and extensively after parenteral administration. Recent published data generated in pigs, cattle and horses show that tulathromycin also accumulates rapidly and extensively in the intra-airway compartment (PELF, BELF, and cells)[1].
Animal Research Animal Models BALB-c mice
Dosages 2.5 mg/kg
Administration i.m.

Chemical Information & Solubility

Molecular Weight 806.08 Formula

C41H79N3O12
CAS No. 217500-96-4 SDF Download Tulathromycin A SDF
Smiles CCCNCC1(C(OC(CC1(C)OC)OC2C(C(C(CC(CNC(C(C(C(OC(=O)C2C)CC)(C)O)O)C)C)(C)O)OC3C(C(CC(O3)C)N(C)C)O)C)C)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (124.05 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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