Home Microbiology Bacterial chemical Octenidine Dihydrochloride

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Octenidine Dihydrochloride Bacterial chemical

Cat.No.S5012

Octenidine, a cationic surfactant, is active against gram-positive and gram-negative bacteria.
Octenidine Dihydrochloride Bacterial chemical Chemical Structure

Chemical Structure

Molecular Weight: 623.83

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Quality Control

Batch: S501201 DMSO]60 mg/mL]false]]]false]]]false Purity: 99.88%
99.88

Solubility

In vitro
Batch:

DMSO : 60 mg/mL (96.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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%
% Tween 80
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 623.83 Formula

C36H62N4.2HCl

 Storage (From the date of receipt)
CAS No. 70775-75-6 -- Storage of Stock Solutions

Synonyms N/A Smiles Cl.Cl.CCCCCCCCN=C1C=CN(CCCCCCCCCCN2C=CC(C=C2)=NCCCCCCCC)C=C1

Mechanism of Action

In vitro
Octenidine binds to negatively charged surfaces like bacterial cell envelopes and eukaryotic cell membranes probably inducing membrane disruption. Its main binding partners are salts of fatty acids glycerol phosphates, found in the cell membranes of mammalian and bacterial cells. Due to this strong and unspecific interaction with bacterial walls it has a broad antimicrobial spectrum against a variety of Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), skin microflora and fungi.
References

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